The Office of Addiction Services and Supports, New York State Department of Health, New York City Department of Health and Mental Hygiene, GNYHA, and participating hospitals are working together to improve the care and outcomes of individuals with related or unrelated complications of opioid use disorder (OUD) in emergency rooms (EDs). The ED Medication-Assisted Treatment (MAT) Quality Collaborative focuses on improving access to evidence-based buprenorphine (a type of MAT), harm reduction, and linkage to comprehensive addiction services in the ED. The use of buprenorphine to treat opioid withdrawal reduces the risk for overdose and OUD-associated harm. The ED MAT Quality Collaborative will follow the Learning Collaborative model in which health care organizations can collaborate cross-functionally, test and measure evidence-based practice innovations, and share experiences to advance widespread adoption of best practices.